Systematic Review: Allogenic Use of Stromal Vascular Fraction and Decellularized Extracellular Matrices as Advanced Therapy Medicinal Products in Tissue Regeneration

July 2020 in “ International Journal of Molecular Sciences ”

Pietro Gentile, Aris Sterodimas, Jacopo Pizzicannella, Laura Dionisi, Domenico De Fazio, Claudio Calabrese, Simone Garcovich

stromal vascular fraction decellularized extracellular matrices advanced therapy medicinal products tissue regeneration allogenic ASCs

TLDR Allogenic ASCs and ECM transplants are safe and effective for tissue regeneration.

The systematic review from 2020 evaluated the allogenic use of stromal vascular fraction (SVF) and decellularized extracellular matrices (ECM) in tissue regeneration, focusing on adipose stem cells (ASCs). Out of 341 studies, 29 met the inclusion criteria, with 19 included in a meta-analysis. The review found that allogenic ASCs and ECM transplants were generally safe and effective, with no major side effects reported. However, it noted a lack of standardized protocols for decellularization and recellularization, complicating result interpretation. The review emphasized the need for well-conducted randomized controlled trials to further assess the safety and efficacy of these therapies and highlighted the importance of adhering to regulatory guidelines.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

Related Community Posts Join

4 / 4 results

community Fresh off the press: Dutasteride may cause chronic infertility

in Research/Science 643 upvotes 9 months ago

Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 1 year ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community This guy claims stem cells fixed his balding

in Is this regrowth? 301 upvotes 2 years ago

A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.