Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis

This study used bidirectional Mendelian Randomization analysis to investigate the causal relationships between 41 inflammatory cytokines and rosacea, involving 1,195 rosacea cases and 211,139 controls. Although no significant correlations were found after Bonferroni correction, potential associations were identified with five cytokines. Higher levels of Stromal Cell-Derived Factor-1α (SDF-1α) and Hepatocyte Growth Factor (HGF) were linked to increased rosacea risk, while higher levels of Stem Cell Factor (SCF), Macrophage Inflammatory Protein-1β (MIP-1β), and Monocyte Chemotactic Protein-1 (MCP-1) were inversely associated with rosacea risk. The study, based on data from the FinnGen database, highlights the complex roles of inflammatory cytokines in rosacea and suggests the need for further research, especially in diverse populations, to confirm these findings and explore underlying mechanisms.