Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels

    January 2018 in “ Biomaterials Science ”
    Justin Tan, Jie Kai Tee, Keat Onn Chou, Shi Ya Au Yong, Jing Pan, Han Kiat Ho, Peiying Ho, Lifeng Kang
    Image of study
    TLDR Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.
    The document from 2018 presents a study that explored how the stiffness of poly(ethylene glycol) diacrylate (PEGDA) hydrogel substrates affects dermal papilla (DP) cell aggregates, which are important for hair follicle formation and growth. The study found that DP cell viability was not significantly affected by the stiffness of the hydrogels. However, cell attachment and spreading were reduced on softer hydrogels, and gene and protein expression analyses indicated that softer substrates (5% PEGDA) led to higher expression of key inductivity markers (Axin2, BMP4, and Noggin) associated with hair follicle regeneration. These results suggest that softer hydrogel substrates may be more suitable for supporting DP cell functions relevant to hair growth. The study included n=3 for rheological and gene expression analysis and n=12 for cell viability assessment, with statistical significance determined by ANOVA tests.
    Discuss this study in the Community →

    Research cited in this study

    16 / 16 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  40 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Vitamin C and hair growth PH levels

      in Product  31 upvotes 4 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Making your own RT1640 in China

      in Research/Science 4 years ago
      RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

      community Extreme hair and beard growth from Stemoxydine. Big 3 + 1?

      in Product  23 upvotes 5 years ago
      Using a combination of Stemoxydine, minoxidil, dutasteride, and keto shampoo to achieve extreme hair and beard growth. The user has experienced positive results with terminal hairs at the hairline and an increase in density to their stubble after several weeks of use.

    Related Research

    3 / 3 results