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GlossaryAxin2

protein regulating Wnt signaling, crucial for hair follicle development

Axin2 is a protein that plays a crucial role in regulating the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, Axin2 is involved in hair follicle development and regeneration, making it significant for understanding conditions like alopecia, where hair loss occurs.

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research Isoxazole 9 (ISX9), a small molecule targeting Axin, activates Wnt/β‐catenin signalling and promotes hair regrowth

11 citations , February 2023 in “British Journal of Pharmacology”

Isoxazole 9 (ISX9) may help regrow hair by activating certain cell signals.

research ISX9, a small molecule targeting Axin, activates Wnt/β-catenin signaling and promotes hair regrowth

August 2022

ISX9 helps regrow hair by activating a specific cell signaling pathway.

research Berberine promotes hair growth by targeting Axin2 and activating Wnt/β-catenin pathway

7 citations , April 2025 in “Phytomedicine”

Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

research Augmenting Endogenous Wnt Signaling Improves Skin Wound Healing

61 citations , October 2013 in “PLoS ONE”

Boosting Wnt signaling improves skin wound healing.

research First-in-human phase 1 study of ETC-159 an oral PORCN inhbitor in patients with advanced solid tumours.

33 citations , May 2017 in “Journal of Clinical Oncology”

ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.

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