Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

    March 2021 in “ Bioactive Materials ”
    Shihao Zhang, Yamin Li, Yamin Li, Xiaofeng Qiu, Anqi Jiao, Wei Luo, Xiajie Lin, Xiaohui Zhang, Zeren Zhang, Jiachan Hong, Peihao Cai, Yuhong Zhang, Yan Wu, Jie Gao, Changsheng Liu, Yulin Li, Yulin Li
    TLDR The developed materials improved wound healing by balancing ROS levels.
    The study developed bioabsorbable materials with ROS-mediation capacity for skin disease therapy by incorporating redox-sensitive poly(N-isopropylacrylamide-acrylic acid) (PNA) nanogels into poly(l-lactic acid) (PLLA) nanofibrous membranes. These PNA-doped membranes improved cell adhesion and proliferation in vitro compared to native PLLA membranes. In vivo studies using a mouse wound skin model showed that these membranes promoted wound healing by adjusting ROS levels through disulfide bonds, enhancing the redox potential and achieving higher wound healing efficacy.
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