Systemic Inflammation Marker Alterations in Severe Alopecia Areata Patients Treated with Janus Kinase Inhibitors

This study investigated systemic inflammatory markers in 129 participants, including 43 patients with severe alopecia areata treated with Janus kinase inhibitors, 43 with mild disease, and 43 healthy controls. It found that markers such as MLR, NLR, PLR, SII, and ESR were significantly higher in severe cases compared to mild cases and controls. In patients with severe alopecia areata who showed clinical improvement after JAK inhibitor therapy, NLR and SII significantly decreased over time, while MLR, PLR, and CRP also reduced, but ESR and RDW remained unchanged. The study suggests an association between systemic inflammation, disease severity, and clinical improvement, though these markers are not definitive predictive biomarkers.