Chronic Inflammation-Mediated Contribution of Bone Marrow-Derived Epithelial Cells and Hair Follicle Stem Cells to Development of Cutaneous Neoplasms

    July 2019 in “ Tumor Biology ”
    Heuijoon Park, Sonali Lad, Kelsey Boland, Kelly Johnson, Nyssa Readio, Guangchun Jin, Samuel A sfaha, Kelly S. Patterson, Ashok Singh, Xiangdong Yang, Douglas Londoño, Anupama Singh, Carol S. Trempus, Derek Gordon, Timothy C. Wang, Rebecca Morris
    TLDR Bone marrow-derived cells contribute to skin tumors, suggesting new treatment targets for non-melanoma skin cancers.
    The study investigated the role of bone marrow-derived epithelial cells (BMDECs) in the development of skin tumors in mice, using a model of chronic inflammation and carcinogenesis. It was found that BMDECs were recruited to over 40% of papillomas, occupying significant portions of the epithelial lesional area, and their recruitment was even greater in dysplastic ulcers. These cells contributed to lesions similarly to hair follicle stem cells. The study also demonstrated that bone marrow cells (BMCs) could produce cytokeratins and migrate towards specific proteins, suggesting a systemic contribution to tumor development. The findings indicated that carcinogen-exposed BMCs could initiate benign and malignant lesions, highlighting potential new targets for treating non-melanoma skin cancers.
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