Systemic Inflammatory Biomarkers In Alopecia Areata: The Role Of SII, SIRI, And CRP/Albumin Ratio

This study examined systemic inflammatory biomarkers in 118 alopecia areata (AA) patients compared to 122 healthy controls, focusing on the systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and CRP/albumin ratio (CAR). The findings revealed that SII levels were significantly higher in AA patients (P<0.001), while SIRI and CAR levels showed no significant difference. Importantly, none of these biomarkers correlated with disease severity, suggesting that systemic inflammation is present even in mild cases of AA.