Integrating Evidence-Based Lifestyle and Adjunct Therapies for Long-Term Management of Polycystic Ovary Syndrome: Mechanistic Insights and Clinical Implications

This narrative review emphasizes the importance of integrating evidence-based lifestyle and adjunct therapies for managing polycystic ovary syndrome (PCOS), a disorder affecting 6%-13% of reproductive-aged women. It highlights the potential benefits of dietary interventions, such as Mediterranean and low-glycemic index diets, and structured physical activities like aerobic and resistance training, in improving metabolic and hormonal outcomes. Adjunct strategies, including nutraceuticals and phytochemicals, may modulate insulin signaling and inflammation, while psychological interventions can enhance treatment adherence. Complementary systems like Ayurveda and Traditional Chinese Medicine are also explored. The review concludes that a balanced, individualized approach combining lifestyle strategies, pharmacological therapies, and adjunct interventions is essential for effective PCOS management, though further high-quality clinical trials are needed to validate these strategies.