Intradermal Injection of Bleomycin Shows Preliminary Evidence of Dermal Fibrosis in a Mouse Model

The study investigates the role of the fibrotic microenvironment in the development of epidermal dyschromia following burn wounds by using a mouse model with bleomycin-induced dermal fibrosis. C57BL/6 mice received intradermal injections of bleomycin at three different doses over two weeks. Histological analysis showed evidence of hair follicle obliteration and dermal thickening, particularly in the high-dose group, indicating successful induction of dermal fibrosis. However, qRT-PCR did not show significant gene expression changes. The study suggests further molecular analyses are needed to confirm bleomycin-induced fibrosis and explore its link to dyschromia.