Associations Between Ionomic Profile and Metabolic Abnormalities in a Murine Model of Sodium Sulfide Induced Alopecia Areata

May 2025 in “ Frontiers in Pharmacology ”

Luning Li, Zhen Sun, Wenxue Sun, You Zhai, Na Ding, Wei Wang

alopecia areata sodium sulfide tofacitinib linoleic acid magnesium unsaturated fatty acids CD8+ T cells hair follicle gut microbiome metabolome autoimmune skin diseases AA JAK inhibitor

TLDR Targeting gut microbiome and metabolome may help treat autoimmune skin diseases like alopecia areata.

This study examines the ionomic and metabolomic profiles in a murine model of sodium sulfide-induced alopecia areata (AA) and the effects of tofacitinib treatment, using 36 male KM mice. It identifies linoleic acid and magnesium as key differential metabolites and ions, with significant changes in unsaturated fatty acids and linoleic acid metabolism. Tofacitinib treatment alters these profiles, reducing CD8+ T cell infiltration and increasing hair follicle count. The study suggests that targeting the gut microbiome and metabolome could be a promising strategy for treating autoimmune skin diseases like AA, highlighting the potential of these metabolic pathways and ions as therapeutic targets.

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