Circulating and/or Cutaneous Irisin Resistance: A Novel Link Among Androgenetic Alopecia, Comorbid Metabolic Syndrome and Cardiovascular Risks

This study examines the relationship between androgenetic alopecia (AGA), metabolic syndrome (MetS), and cardiovascular risks, focusing on the role of irisin, a hormone linked to energy metabolism. Conducted on 44 AGA patients and 22 healthy controls, the research found that AGA is associated with increased cardiovascular and metabolic risks, including higher BMI, hypertension, and dyslipidemia. AGA patients had significantly higher serum irisin levels, which correlated positively with BMI and carotid intima-media thickness (CIMT), suggesting irisin resistance and a potential link to cardiovascular risk. The study suggests that irisin levels could serve as a predictor for MetS and cardiovascular risks in AGA patients, highlighting the potential of irisin as a biomarker for these comorbidities. However, further research is needed to fully understand its role and receptor interactions.