Practices, Efficacy, and Reported Side Effects Associated with Isotretinoin Treatment in Palestine

This study on isotretinoin treatment in Palestine, involving 548 participants, reveals significant nonadherence to international guidelines, particularly in monitoring and counseling practices. Despite common side effects like dry lips and skin, 47.4% of participants were satisfied with the treatment, though 35.6% experienced acne recurrence. Alarmingly, 5.3% of patients used isotretinoin without a prescription, and 39.8% of physicians prescribed it for unsupported indications. Additionally, 18.4% of patients took contraindicated medications concurrently. The study emphasizes the need for improved prescribing practices, patient education, and adherence to safety protocols to enhance treatment efficacy and safety. Further research with larger, diverse populations is recommended.