Preparation and Physicochemical Evaluation of Topical Cream Ivermectin 1% for Treatment of Rosacea

The study successfully formulated a stable topical cream containing 1% ivermectin for the treatment of rosacea, a condition linked to Demodex mites. Over a six-month period, the cream maintained its physical stability, with no changes in appearance, density, viscosity, pH, or uniformity, and showed no microbial contamination. The findings suggest that this ivermectin cream could reduce the need for chronic antibiotic use in rosacea treatment, providing a high-potential alternative for physicians to prescribe.