Cellular Response of Keratinocytes to the Entry and Accumulation of Nanoplastic Particles
April 2024
in “
Particle and Fibre Toxicology
”
keratinocytes nanoplastics stratum corneum 3D keratinocyte/dermal fibroblast co-culture transepidermal transport IL-17 signaling pathway myofibroblast α-smooth muscle actin pro-Collagen Ia skin inflammation immune responses skin cells plastic particles skin barrier skin model skin transport inflammatory pathway muscle actin collagen production skin irritation immune system
TLDR Nanoplastics can penetrate skin cells, triggering inflammation and immune responses.
This study examines the effects of nanoplastic particles (NPs) on human skin, focusing on keratinocytes and dermal fibroblast cells. Using in vitro and 3D co-culture models, researchers found that 100 nm NPs can penetrate the skin, especially when the stratum corneum is compromised, leading to accumulation in skin cells. NPs were shown to alter gene expression related to inflammation in keratinocytes and induce a transition in dermal fibroblasts to myofibroblast cells, increasing α-smooth muscle actin and pro-Collagen Ia production. These changes suggest potential skin inflammation and immune responses, highlighting the risks of NP exposure, particularly for individuals with compromised skin barriers.
