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Protective Role of Agomelatine via Modulation of TLR4/NF-κB: NLRP3/IL-1β Signaling Pathways in Testosterone-Induced Benign Prostatic Hyperplasia in Rats

research Protective role of agomelatine via modulation of TLR4/NF-κB: NLRP3/IL-1β signaling pathways in testosterone-induced benign prostatic hyperplasia in rats

December 2025 in “Naunyn-Schmiedeberg s Archives of Pharmacology”

Agomelatine may help reduce benign prostatic hyperplasia by blocking certain inflammatory pathways.

Network Pharmacology and In Vivo Experimental Analysis for Validating the Antifibrotic Potential of Punica Granatum Leaves Against Skin Scleroderma: The Role of Oxidative Stress, Inflammation and TGF-β1/Snail 1/p-Smad 3 Signaling Pathway

research Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway

April 2026 in “Inflammopharmacology”

Punica granatum leaf extract may help treat skin fibrosis by reducing inflammation and oxidative stress.

research The common regulatory pathway of COVID-19 and multiple inflammatory diseases and the molecular mechanism of cepharanthine in the treatment of COVID-19

15 citations , July 2022 in “Frontiers in Pharmacology”

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

research The IL-23/IL-17 Pathway in Inflammatory Skin Diseases: From Bench to Bedside

144 citations , November 2020 in “Frontiers in immunology”

Targeting the IL-23/IL-17 pathway effectively treats several inflammatory skin diseases.

research Cellular response of keratinocytes to the entry and accumulation of nanoplastic particles

26 citations , April 2024 in “Particle and Fibre Toxicology”

Nanoplastics can penetrate skin cells, triggering inflammation and immune responses.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Creatine Doesn’t Cause Hair Loss: Stop the BS

in Research/Science 140 upvotes 9 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 677 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Hair Loss “Cure” for Inflammation: Topical Roflumilast

in Research/Science 32 upvotes 6 months ago

Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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