TLDR Keratinocyte stem cells are crucial for skin renewal and have potential in wound healing and tissue regeneration.
This review explores the role of keratinocyte stem cells (KSCs) in epidermal renewal, focusing on their ability to balance self-renewal and differentiation through three "fate locks": identity switch, cell-cycle lock, and mechanotransduction lock. It discusses how external signals and intrinsic mechanisms guide KSC fate, and highlights advancements in isolating and expanding human keratinocytes. The review also covers 3D models, hydrogel delivery systems, and keratinocyte-derived products for wound healing, while noting emerging applications in immunomodulation, pigment restoration, and regeneration of ocular and mucosal tissues.
9 citations
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October 2024 in “Burns & Trauma” Air-liquid interface culture improves hair follicle development in skin organoids.
August 2023 in “Military Medical Research” Scientists have improved 3D models of human skin for research and medical uses, but still face challenges in perfectly replicating real skin.
44 citations
,
July 2020 in “Stem Cell Research & Therapy” Epidermal stem cells show promise for skin repair and regeneration.
129 citations
,
July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
40 citations
,
January 2016 in “Elsevier eBooks” The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.
266 citations
,
January 2016 in “Development” YAP and TAZ are crucial for skin cell growth and repair.
28 citations
,
September 2011 in “Stem Cell Reviews and Reports” 
291 citations
,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.
13 citations
,
December 2001 in “Journal of Investigative Dermatology” Overexpressing ornithine decarboxylase and v-Ha-ras in keratinocytes leads to invasiveness and malignancy.
85 citations
,
July 2012 in “Cold Spring Harbor perspectives in biology” The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.
7 citations
,
February 2022 in “Stem cell reviews and reports” Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.
133 citations
,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
54 citations
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October 2023 in “Oncogene” p63 is essential for controlling epithelial stem cells and tissue health.
