YAP/TAZ Signaling Controls Epidermal Keratinocyte Fate

November 2024 in “ International Journal of Molecular Sciences ”

M. D. Pankratova, Andrei Riabinin, Elizaveta A. Butova, Arseniy V. Selivanovskiy, Elena I. Morgun, Sergey V. Ulianov, Е. A. Vorotelyak, Ekaterina P. Kalabusheva

YAP TAZ epidermal keratinocytes Hippo pathway cell proliferation cell fate skin regeneration carcinogenesis growth factors cytokines extracellular matrix

TLDR YAP and TAZ proteins control skin cell growth and repair.

The review discusses the role of Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in controlling cell proliferation and fate in epidermal keratinocytes. YAP and TAZ are crucial for both homeostatic cell renewal and injury-induced regeneration in the skin, and they also contribute to carcinogenesis and other pathologies. While typically downstream of the Hippo pathway, YAP and TAZ serve as central integrators of the signalling microenvironment, interacting with growth factors, cytokines, and extracellular matrix parameters. The review highlights how YAP/TAZ-mediated signalling collaborates with other molecules across different cellular levels to regulate transcription programs that determine epidermal cell fate.

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