Screening the Key Genes of Hair Follicle Growth Cycle in Inner Mongolian Cashmere Goat Based on RNA Sequencing

May 2020 in “ Archiv für Tierzucht ”

Rui Su, Guoyi Gong, Lingtian Zhang, Xiaochun Yan, Fenghong Wang, Lei Zhang, Xuguang Qiao, Xiaokai Li, Jinquan Li

hair follicle growth cycle RNA sequencing differentially expressed genes anagen catagen telogen FGF5 FGFR1 RRAS MAPK signaling pathway hair growth cycle gene expression growth phase regression phase resting phase

TLDR Researchers identified genes that may affect hair growth in Cashmere goats.

In 2020, researchers conducted a study on Inner Mongolian Cashmere goats to identify key genes involved in the hair follicle growth cycle. Using RNA sequencing on skin samples from three 2-year-old female goats at different stages of the hair growth cycle, they found 51 differentially expressed genes (DEGs) between the anagen and catagen stages, 443 DEGs between catagen and telogen, and 779 DEGs between telogen and anagen. The most DEGs were found between the telogen and anagen stages. The study identified three genes - FGF5, FGFR1, and RRAS - that may impact hair follicle growth and development through the MAPK signaling pathway. These findings provided a basis for further research on hair growth and potential treatments for hair loss.

View this study on aab.copernicus.org →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research The Mechanism of Activated Platelet-Rich Plasma Supernatant Promotion of Hair Growth by Cultured Dermal Papilla Cells

14 citations , March 2019 in “Journal of Cosmetic Dermatology”

Activated platelet-rich plasma helps hair growth by boosting growth factors and cell growth pathways in hair cells.

Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

research Melatonin Promotes Secondary Hair Follicle Development in Early Postnatal Cashmere Goats and Improves Cashmere Quantity and Quality by Enhancing Antioxidant Capacity and Suppressing Apoptosis

46 citations , March 2019 in “Journal of Pineal Research”

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

25 citations , February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations , October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

Effects of Photoperiod on Nutrient Digestibility, Hair Follicle Activity, and Cashmere Quality in Inner Mongolia White Cashmere Goats

research Effects of Photoperiod on Nutrient Digestibility, Hair Follicle Activity, and Cashmere Quality in Inner Mongolia White Cashmere Goats

11 citations , August 2018 in “Asian-Australasian journal of animal sciences”

Short daily photoperiods improve cashmere production in Inner Mongolia white cashmere goats.

Dietary Supplementation with Essential Oils and Cobalt for Improving Growth Performance, Meat Quality, and Skin Cell Capacity of Goats

research Dietary Supplementation with Essential Oils and Cobalt for Improving Growth Performance, Meat Quality, and Skin Cell Capacity of Goats

32 citations , July 2018 in “Scientific Reports”

Essential-oils-cobalt improves goat growth and product quality.

research Gene Expression and Localization of LAMTOR3 in the Skin Cells of Liaoning Cashmere Goats

4 citations , March 2018 in “Animal biotechnology”

The LAMTOR3 gene is involved in cashmere goat hair growth and is affected by certain treatments and other genes.

research The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family

14 citations , December 2016 in “PloS one”

Keratin 26 affects cashmere goat hair growth and is influenced by various treatments.

research Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

104 citations , October 2016 in “PLoS ONE”

CRISPR/Cas9 gene editing in cashmere goats increases hair follicles and fiber length, boosting cashmere yield.

research A Microarray-Based Analysis Reveals That a Short Photoperiod Promotes Hair Growth in the Arbas Cashmere Goat

40 citations , January 2016 in “PLoS ONE”

Shorter daylight increases hair growth in Cashmere goats.

research Gab1 and MAPK Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence

36 citations , October 2015 in “Cell reports”

Gab1 protein is crucial for hair growth and stem cell renewal, and Mapk signaling helps maintain these processes.

research The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration

66 citations , July 2015 in “Journal of Molecular Biology”

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations , April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.

Related Community Posts Join

6 / 1000+ results

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 year ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community My Theory Of Androgenic Alopecia

in Research/Science 17 upvotes 1 month ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community How do we only have two treatments to combat hair loss at this point in time?

in Chat 211 upvotes 2 years ago

The post discusses frustration over the limited and not always effective treatments for hair loss, mainly Minoxidil and Finasteride. The conversation includes mentions of potential new treatments like GT20029, HMI-115, CosmeRNA, KX-826, and microneedling, but also highlights the challenges of funding and prioritizing research in this area.

community PP405 Won't Work Long Term: Hair Follicle Damage Due to Abuse of the ISR System

in Research/Science 59 upvotes 2 months ago

PP405 may damage hair follicles if used long-term, suggesting cycling might be necessary. Combining it with finasteride could help maintain hair growth.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 2 years ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

Related Research

8 / 8 results

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

2 citations , February 2022 in “Genomics”

Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations , April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

22 citations , July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture”

Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.

research Review of Hair Follicle Dermal Cells

321 citations , December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.