Safety and Clinical Efficacy of Kūlaris, an Herbal Supplement for Mild to Severe Acne Vulgaris: A 12-Week Randomized, Double-Blind, Placebo-Controlled Study

The study investigated the efficacy and safety of Kūlaris, an herbal supplement, for treating mild to severe acne vulgaris in a 12-week randomized, double-blind, placebo-controlled trial involving 100 participants aged 18-40. Participants received either 450 mg of Kūlaris or a placebo daily. Results showed a significant improvement in quality of life for those taking Kūlaris, although no significant changes were observed in general skin health measures like skin quality, color, wrinkle reduction, and hydration. Kūlaris was well tolerated with no adverse effects reported, suggesting its potential as a therapeutic or adjunctive treatment for acne vulgaris.