Lactiplantibacillus Plantarum ZJUIDS51 Improves Androgenic Alopecia via Gut-Skin Axis

    February 2026 in “ Food Research International
    Jinfeng Fu, Yanghui He, Lulu Qiao, Zeyu Wu, Yuan Wei, Eng Huan Hau, Ying Xiao, Daxi Ren
    The study concludes that supplementation with the food-derived strain Lactiplantibacillus plantarum ZJUIDS51 effectively improves androgenic alopecia (AGA) by promoting hair regrowth and restoring follicular health. The mechanism involves remodeling the gut-skin metabolic axis, modulating steroid homeostasis, and increasing plant-derived antioxidative metabolites. These changes help reduce cutaneous dihydrotestosterone (DHT) levels and oxidative stress. The findings suggest that ZJUIDS51 could serve as a safer, functional food alternative to current AGA treatments like minoxidil and finasteride, which have safety concerns.
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