Lambertianic Acid from Platycladus Orientalis Inhibits Muscle Atrophy in Dexamethasone-Induced C2C12 Muscle Atrophy Cells

The study examines the effects of lambertianic acid (LA) from Platycladus orientalis on muscle atrophy in C2C12 myotubes induced by dexamethasone. LA at concentrations of 25 µM and 50 µM improved myotube diameter and reduced the expression of atrophy-related proteins MuRF-1 and Atrogin-1, without affecting cell viability. These findings suggest that LA has protective effects against skeletal muscle atrophy and potential as a natural therapeutic candidate for muscle-wasting disorders. Further research is needed to evaluate its effectiveness in other models and in vivo studies.