The High-Polarity Fraction of Tail Fat Derived from Lanzhou Fat-Tailed Sheep Enhances Skin Wound Healing Through the Regulation of Inflammatory Factors and the TGF-β1/Smad3 Signaling Pathway
June 2026
in “
Food Science and Human Wellness
”
TLDR Tail fat from Lanzhou Fat-Tailed sheep helps heal skin wounds by reducing inflammation and promoting tissue repair.
The study investigates the effects of the high-polarity fraction (HPF) of tail fat from Lanzhou Fat-Tailed sheep on skin wound healing. The HPF demonstrated significant antioxidant activity and improved wound healing in a mouse model by reducing inflammation and promoting collagen production. It decreased pro-inflammatory cytokines IL-1β and TNF-α while increasing TGF-β1, a growth factor, in the skin. HPF also accelerated hair follicle and sebaceous gland generation, aiding in scar prevention. The study found that HPF upregulated TGF-β1 and downregulated Smad3, enhancing the healing process through the TGF-β1/Smad3 signaling pathway.
