Lysine Carboxymethyl Cysteinate Protects the Epidermis from UVB-Induced Barrier Damage Through the Activation of Autophagy

Lysine carboxymethyl cysteinate (LCC) has been shown to protect the epidermis from UVB-induced damage by activating autophagy. In a study using a 3D living skin equivalent model, LCC restored epidermal cell thickness by 9.67% and significantly increased the expression of biomarkers related to skin hydration and cornified envelope formation. Transcriptomics analysis in human keratinocytes revealed that LCC influences glutathione synthesis, oxidation response, inflammation, and autophagy. The protective effects of LCC, particularly in barrier formation and autophagy, were confirmed and shown to be negated by chloroquine, an autophagy inhibitor. These findings highlight LCC's potential in safeguarding skin integrity against UVB damage.