Regulatory Role of LEF-1 in the Proliferation of Arbas White Cashmere Goat Dermal Papilla Cells

April 2018 in “ Canadian Journal of Animal Science ”

Fei Hao, Wei Yan, Xiaodong Guo, Bing Zhu, Dongjun Liu

LEF-1 dermal papilla cells hair follicle growth β-catenin C-myc cyclin D1 Wnt signaling pathway DPCs Wnt pathway

TLDR LEF-1 boosts cell growth in goat hair follicles, aiding cashmere production.

The study explored the role of LEF-1 in the proliferation of dermal papilla cells (DPCs) from Arbas White Cashmere goats, emphasizing the Wnt signaling pathway. Researchers found that overexpression of LEF-1 increased the expression of β-catenin, C-myc, and cyclin D1, enhancing cell proliferation, while interference with LEF-1 decreased these expressions and reduced proliferation. This pattern was observed in both primary and secondary DPCs, indicating that LEF-1 regulated cell proliferation through Wnt signaling in both cell types. The findings provided insights into genetic mechanisms that could enhance cashmere production by influencing hair follicle growth and development.

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