TLDR Rat hair follicle stem cells can be used to improve blood vessel growth in engineered skin.
The study investigated the use of rat hair follicle stem cells (rHFSCs) transfected with VEGF165 via lentivirus vectors to enhance vascularization in tissue-engineered skin. The rHFSCs were isolated from 1-week-old Sprague-Dawley rats and achieved a high transfection rate of 85.8±1.9%, expressing significant levels of VEGF165 mRNA and protein. This indicated that rHFSCs could be a promising cell source for developing tissue-engineered hair follicles, vessels, and skin, addressing the challenge of poor vascularization in tissue-engineered skin.
121 citations
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June 2009 in “Journal of Cellular Biochemistry” Human hair follicle stem cells can safely and effectively help nerve regeneration.
344 citations
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June 2006 in “American Journal Of Pathology” Human hair follicles can provide stem cells for regenerative medicine.
February 2014 in “PubMed” Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.
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October 2014 in “Stem cell research & therapy” Modified rat stem cells on a special scaffold improved blood vessel formation and wound healing in skin substitutes.
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