Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

    May 2024 in “ Advanced NanoBiomed Research ”
    Lamyaa Albakr, Hongyuan Du, Xiyuan Zhang, Himanshu Kathuria, Ahmed Fahmi Anwar‐Fadzil, Nial Wheate, Lifeng Kang
    TLDR Nanocarriers can improve skin drug delivery but face challenges in clinical use.
    The document reviews advancements in lipid and inorganic nanocarriers for enhanced skin drug delivery, emphasizing their potential to improve drug absorption, stability, and bioavailability. It discusses various nanocarriers like liposomes, ethosomes, and inorganic nanoparticles, focusing on their mechanisms for controlled release and deeper skin penetration. Despite their promise, few have been successfully implemented in clinical settings. The review highlights the importance of nanocarrier physicochemical properties and provides examples, such as lipid nanoparticles improving the stability and delivery of drugs like isoflavone orobol. It also addresses preparation and scale-up methods, underscoring ongoing research and future challenges in the field. Notably, a study developed a system for treating androgenic alopecia using nanostructured lipid carriers loaded with β-sitosterol, significantly enhancing hair growth in rats. Overall, these nanocarriers show promise for various dermatological applications, including hair regrowth and skin condition treatments.
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