Liposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability

February 2024 in “ Pharmaceutics ”

Nina Dragičević, Howard I. Maïbach

liposomes nanocarriers phospholipid-based nanocarriers acne vulgaris retinoids antibiotics nanotechnology vesicles acne nanotech

TLDR Nanocarriers can make acne treatments more effective and gentle on the skin.

The article discusses the use of nanotechnology, specifically phospholipid-based nanocarriers such as liposomes, to improve the treatment of acne vulgaris. Acne affects about 85% of teenagers and is typically treated with topical agents like retinoids and antibiotics, which can cause side effects like dryness and redness. The study highlights how nanocarriers can enhance the therapeutic efficacy and skin tolerability of these treatments, potentially reducing side effects and improving patient compliance. Additionally, the article explores novel active ingredients encapsulated in vesicles that go beyond current treatment guidelines.

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Liposomes and Other Nanocarriers for the Treatment of Acne Vulgaris: Improved Therapeutic Efficacy and Skin Tolerability

Research cited in this study

research Guidelines of Care for the Management of Acne Vulgaris

research Optimization, Characterization, and Follicular Targeting Assessment of Tretinoin and Bicalutamide Loaded Niosomes

research Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders

research A Liposome-Based Formulation Containing Equol, Dihomo-γ-Linolenic Acid, and Propionyl-L-Carnitine to Prevent and Treat Hair Loss: A Prospective Investigation

research Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers

research Anti-MRSA Malleable Liposomes Carrying Chloramphenicol for Ameliorating Hair Follicle Targeting

research Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability

research Development and Characterization of Polymeric Nanoparticle-Based Formulation of Adapalene for Topical Acne Therapy

research Intradermal and Follicular Delivery of Adapalene Liposomes

research Hair Follicles as a Target Structure for Nanoparticles

research Development, Formulation, and Characterization of an Adapalene-Loaded Solid Lipid Microparticle Dispersion for Follicular Penetration

research Selective Induction of Apoptosis in the Hamster Flank Sebaceous Gland Organ by a Topical Liposome 5-Alpha-Reductase Inhibitor: A Treatment Strategy for Acne

research The Influence of Selected Steroid Hormones on the Physicochemical Behavior of DPPC Liposomes

research Tea Tree Oil Concentration in Follicular Casts After Topical Delivery: Determination by High-Performance Thin Layer Chromatography Using a Perfused Bovine Udder Model

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