Lupeol: An Updated Review Utilizing AI-Assisted Predictive Tools for Enhanced Therapeutic Insights Into Lupeol’s Potential for Alopecia Management

    Aya M. Mustafa, Riham A. El‐Shiekh, Safaa A. Faheem, Mariam H. Fawzy, Mohamed A. Said, Ahmed F. Mohamed, Shymaa Hatem, Asmaa A. Mandour
    TLDR Lupeol shows promise for hair growth but needs better absorption and safety testing.
    The review examines lupeol's (LUP) potential for alopecia management, highlighting its anti-inflammatory and hair growth-promoting properties. AI-assisted tools reveal LUP's interaction with key protein targets and pathways, such as EGFR and PTGS2, which are crucial for hair follicle regeneration and inflammation modulation. Despite its promise, LUP faces challenges like low bioavailability and limited toxicity testing. The review suggests that future research should focus on improving LUP's bioavailability and conducting thorough safety evaluations to fully realize its therapeutic potential for alopecia.
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