Human Macrophages Preferentially Infiltrate the Superficial Adipose Tissue

    May 2018 in “ International Journal of Molecular Sciences ”
    Giuseppe Cappellano, Evi M. Morandi, Johannes Michael Rainer, Philipp Grubwieser, Katharina Heinz, Dolores Wolfram, David Bernhard, Susanne Lobenwein, Gerhard Pierer, Christian Ploner
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    TLDR Human body's immune cells are more common in the layer of fat just beneath the skin than in deeper fat layers.
    The study focused on the differences between human superficial adipose tissue (SAT) and deep adipose tissue (DAT), particularly in terms of immune cell infiltration and the properties of adipose-derived stem cells (ASCs). It was found that SAT contained larger primary adipocytes and a higher number of tissue-infiltrating macrophages compared to DAT. ASCs from SAT also showed faster proliferation and greater differentiation potential. The study involved 14 female patients with a mean age of 43.6 years and a mean BMI of 25.1 kg/m². The findings suggest that SAT may have a higher regenerative potential and that its proximity to skin microbiota could explain the increased macrophage infiltration. This could have implications for therapeutic approaches using ASCs. However, the document also included a section that could not be parsed as it did not provide specific results or conclusions.
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