The Role of Mast Cells in Skin Aging: Mechanisms and Therapeutic Advances
October 2025
in “
Experimental Dermatology
”
TLDR Mast cells influence skin aging and are potential targets for anti-aging treatments.
Mast cells (MCs) are key regulators in skin aging, acting as sensors and amplifiers of aging-related signals. They release mediators that activate pathways like FcεRI, c-KIT, TLRs, and MRGPRX2, affecting fibroblasts, keratinocytes, melanocytes, and immune cells, and creating feedback loops that enhance aging processes. MCs have dual roles, both protecting and accelerating skin aging, making them promising therapeutic targets. Treatments such as MC stabilisers (ketotifen, luteolin) and phototherapy show potential in reducing skin aging. Further research is needed to understand mechanisms and optimize therapies for precision medicine.
