Maternal Obesity and the Metabolic Syndrome in Reproductive Health: Assessing Incretin-Based Interventions

The review addresses the impact of the global obesity epidemic on reproductive health, emphasizing the need for effective weight loss interventions during gestation to improve maternal and fetal health outcomes. It explores surgical and pharmacological strategies, with a focus on incretin-based therapies like GLP-1 receptor agonists and GIP dual agonists, which may enhance reproductive function and adapt to metabolic changes in pregnancy. These changes involve insulin signaling, lipid metabolism, and inflammatory regulation. The review also highlights the long-term risks of maternal obesity, such as increased likelihood of childhood obesity, underscoring the importance of managing gestational weight gain.