Mechanotransduction in Androgenetic Alopecia: An In Silico Repositioning Study of PIEZO1 and MLCK Axis Using Cofolding and Pilosebaceous Single-Cell Atlas Constraints

A recent study explores a non-androgen pathway for treating androgenetic alopecia (AGA) by targeting the PIEZO1 and MLCK axis, which is implicated in follicular miniaturization due to connective tissue sheath hypercontractility. The research screened a library of 2,529 natural compounds using advanced computational methods to identify candidates that could potentially inhibit this pathway, with promising bioavailability for topical application. However, these findings are purely computational and require further *in vitro* validation, with no current clinical claims or products available.