Menopause and Dermal White Adipose Tissue Depletion: Mechanistic Links, Adipogenesis, and Regenerative Therapeutic Replacement

The study explores the impact of menopause on dermal white adipose tissue (dWAT) and its role in skin health. Menopause-related estrogen decline disrupts adipogenic pathways, leading to reduced dWAT, affecting dermal thickness and structure. The research highlights magnolol and PLLA-SCA as potential treatments to promote adipogenesis and restore healthy adipose tissue, improving skin plumpness, texture, and elasticity. This dual approach, combining injectable boosters and topical maintenance, offers a new therapeutic paradigm for rejuvenating menopausal skin. While direct measurement of dWAT in menopause is not yet established, evidence supports the potential of these interventions.