Skin Aging: Are Adipocytes the Next Target?

The document discussed the role of dermal white adipose tissue (dWAT) in skin aging, highlighting its unique effects and phenotypic changes. It noted that both intrinsic and extrinsic aging, particularly chronic photo-damage, led to a reduction in dWAT volume due to adipocytes being replaced by fibrotic structures, a process known as "adipocyte-myofibroblast transition" (AMT). The study also suggested that dermal adipocytes might contribute to skin aging, as indicated by the correlation between hypertrophic scarring and signs of aging across different ethnic groups. These findings suggested that targeting dermal adipocytes could be a promising strategy for combating skin aging.