Applications of Mesenchymal Stem Cells in Anti-Aging and Skin Regeneration

February 2026 in “ MedScien ”

Jinmeng Zhou

mesenchymal stem cells paracrine activity growth factors cytokines exosomes oxidative stress collagen synthesis matrix metalloproteinase angiogenesis photodamaged skin diabetic foot ulcers MSCs

TLDR Mesenchymal stem cells can help delay skin aging and improve wound healing.

This paper reviews the role of mesenchymal stem cells (MSCs) in anti-aging and skin regeneration, highlighting their mechanisms of action and clinical effectiveness. MSCs primarily function through paracrine activity, releasing growth factors, cytokines, and exosomes that protect against oxidative stress, modulate the immune system, promote collagen synthesis, inhibit matrix metalloproteinase activity, and stimulate angiogenesis. These actions help delay skin aging and enhance wound healing, particularly in photodamaged skin and diabetic foot ulcers. While MSCs show promise, further research is needed on cell standardization, safety, and cell-free therapies.

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