Efficacy and Safety of Mesotherapy With 0.5% Minoxidil Versus Topical 2% Minoxidil for Female Androgenetic Alopecia: A Randomized Controlled Trial

This randomized controlled trial compared the efficacy and safety of mesotherapy with 0.5% minoxidil injections versus topical 2% minoxidil in treating female androgenetic alopecia (FAGA) over 16 weeks, involving 40 women. The mesotherapy group showed significantly greater improvements in hair density, diameter, and coverage, with hair density increasing from 33.10 to 41.80 hairs/cm² and hair diameter from 62.03 to 76.20 μm. Both treatments were well-tolerated, with no severe adverse effects reported. The study suggests that mesotherapy with 0.5% minoxidil is a safe and potentially more effective alternative to topical application, especially for patients who cannot tolerate or respond poorly to topical treatments. However, limitations include the small sample size and short duration, indicating a need for further research with larger samples and longer follow-up.