Mon-323 Metastatic Adrenocortical Carcinoma Presenting With Mixed Cushing's And Virilization Syndrome Along With Bilateral Pulmonary Emboli

The document described a clinical case of a 57-year-old woman with metastatic adrenocortical carcinoma presenting with mixed Cushing's and virilization syndrome, along with bilateral pulmonary emboli. The patient exhibited symptoms such as male pattern balding, body hair growth, and severe hirsutism, with significant laboratory findings including elevated serum cortisol and testosterone levels. Imaging revealed a large retroperitoneal mass and metastatic disease in multiple locations. The patient was treated with a combination of mitotane, cisplatin, doxorubicin, and etoposide. The study concluded that rapid virilization should prompt evaluation for underlying malignancy, particularly adrenal or ovarian tumors.