Methotrexate to Treat SAPHO Syndrome with Keloidal Scars

The document reported a case of a 42-year-old man with SAPHO syndrome, a rare condition characterized by skin lesions and joint issues. Initially treated for severe acne, the patient developed keloidal scars and polyarthritis over time. Despite previous treatments, significant improvement was observed after starting methotrexate at 10 mg per week, later increased to 20 mg per week, along with finasteride 5 mg per day. The case highlighted the challenges in diagnosing SAPHO syndrome and the effectiveness of methotrexate in managing symptoms, despite the progression to keloids.