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GlossaryMethotrexate

inhibits cell growth by blocking folic acid metabolism

Methotrexate (MTX) is a medication commonly used to treat certain types of cancer, autoimmune diseases like rheumatoid arthritis, and severe psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for the rapid growth of cells, thereby slowing down the proliferation of cancer cells and modulating the immune system.

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research Methotrexate in the treatment of steroid-dependent asthma

80 citations , August 1991 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Methotrexate reduced the need for steroids in asthma patients without worsening their condition.

research Efficacy and tolerability of methotrexate in severe childhood alopecia areata

70 citations , April 2011 in “British journal of dermatology/British journal of dermatology, Supplement”

Methotrexate sometimes helps regrow hair in children with severe alopecia areata and is generally safe.

research Methotrexate for induction of remission in ulcerative colitis

53 citations , August 2014 in “Cochrane library”

Methotrexate is not proven effective for inducing remission in ulcerative colitis.

research Methotrexate for maintenance of remission in ulcerative colitis

51 citations , August 2015 in “Cochrane library”

Methotrexate is not proven to maintain remission in ulcerative colitis.

research Efficacy and safety of methotrexate in alopecia areata

44 citations , August 2014 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

Methotrexate is a promising and safe treatment for severe alopecia areata, with better results when combined with corticosteroids.

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