Microneedles as an Emerging Platform for Transdermal Delivery of Phytochemicals

Microneedles (MNs) are a promising technology for enhancing the transdermal delivery of phytochemicals, offering improved bioavailability and reduced systemic side effects. They effectively bypass the skin barrier, making them suitable for treating conditions like alopecia, cancer, and chronic wounds. MNs come in various forms, such as solid, coated, hollow, dissolving, and hydrogel-forming, each with unique benefits. In alopecia, MNs enhance the delivery of compounds like EGCG and quercetin, promoting hair growth by activating hair follicle stem cells. Despite their potential, challenges like manufacturing inconsistencies and the need for further clinical studies remain. Overall, MNs represent a significant advancement in transdermal drug delivery, with potential applications in various therapeutic areas.