Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

    August 2024 in “ Acta Pharmaceutica Sinica B
    Chaoxiong Wu, Qingyu Yu, Chenlu Huang, Fangzhou Li, Linhua Zhang, Dunwan Zhu
    TLDR Microneedles can improve skin disease treatment by delivering drugs directly through the skin.
    Microneedles (MNs) represent a groundbreaking method in transdermal drug delivery, effectively overcoming the skin's barriers to enhance treatment for skin diseases. This review highlights MNs' ability to bypass the stratum corneum, delivering drugs directly to the subdermal matrix, and discusses various MN types, such as solid, coated, hollow, hydrogel, and dissolvable, each with specific applications. MNs show promise in treating cutaneous cancers, inflammatory dermatoses, and wound management, with potential in aesthetic dermatology. However, challenges like dosage calibration, biocompatibility, and regulatory issues must be addressed to fully harness MNs' therapeutic potential. Continued research and innovation are crucial for their successful clinical adoption.
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