Minoxidil-Induced Hypertrichosis: Pathophysiology, Clinical Implications, and Therapeutic Strategies

This review discusses the issue of hypertrichosis, or excessive hair growth, as a side effect of low-dose oral minoxidil therapy for alopecia. It explores the mechanisms by which minoxidil promotes hair growth, such as vasodilation and growth factor expression, which can also lead to unintended systemic absorption and hypertrichosis. The review highlights the psychosocial impact of this side effect and stresses the importance of tailored therapeutic strategies, comprehensive patient counseling, and a collaborative, patient-centric approach. By addressing hypertrichosis in a patient-centered manner, clinicians can help mitigate distress and improve patients' quality of life, underscoring the need for multidisciplinary care and ongoing support.