Chronic Treatment with Minoxidil Induces Elastic Fiber Neosynthesis and Functional Improvement in the Aorta of Aged Mice

    June 2017 in “ Rejuvenation Research ”
    Marion Coquand-Gandit, Marie-Paule Jacob, Wassim Fhayli, Beatriz Romero, Miglena Georgieva, Stéphanie Bouillot, Eric Estève, Jean-Pierre Andrieu, Sandrine Brasseur, Sophie Bouyon, Natalio García-Honduvilla, Philippe Huber, Julia Buján, Milena Atanasova, Gilles Faury
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    TLDR Minoxidil treatment increases aorta elasticity and reduces stiffness in aged mice, potentially helping with age-related heart issues.
    Chronic treatment with minoxidil improved the function of the aorta in aged mice by inducing the production of new elastic fibers, resulting in increased elasticity and reduced stiffness. The study involved 7 untreated mice and 9 minoxidil-treated mice, and the treatment resulted in a significant difference in wall thickness and improved aortic reactivity. This suggests that minoxidil could be a potential treatment for age-related arterial stiffness and related cardiovascular diseases.
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