Preparation And Evaluation Of Minoxidil Nanoemulgel Topical Formulations

This study focused on developing a nanoemulsion-based gel formulation of minoxidil to improve its delivery for hair loss treatment. Traditional topical solutions of minoxidil face challenges such as short contact time with the scalp, poor drug penetration, and the need for high doses. The new formulation aimed to address these issues by using clove oil as the oil phase, Tween® 80 as the surfactant, ethanol as the co-surfactant, and distilled water as the aqueous phase, with propylene glycol as the co-solvent. The goal was to prolong the contact time of minoxidil on the scalp and enhance its skin permeation, potentially improving its efficacy in treating hair loss.