Minoxidil–2-Hydroxypropyl-β-Cyclodextrin Inclusion Complexes: Characterization and In Vivo Evaluation of an Aqueous Solution for Hair Growth in Rats

    March 2017 in “ Journal of inclusion phenomena and macrocyclic chemistry ”
    Ta Liang Chen, Song Yu, Chin Wang Hsu, Fuu Jen Tsai, Yuhsin Tsai
    Image of study
    TLDR Minoxidil mixed with 2-hydroxypropyl-β-cyclodextrin in water can improve hair growth more than minoxidil alone.
    In 2017, researchers developed a water-soluble complex of minoxidil and 2-hydroxypropyl-β-cyclodextrin (HP-ß-CD) to improve hair growth treatment. The complex was confirmed to be water-soluble and was tested on rats. Both the complex and minoxidil alone significantly promoted hair growth by day 14, but the complex had a slightly higher effect, suggesting it targeted more drug to the hair follicles. The study concluded that replacing the organic solvent in minoxidil topical solution with water is feasible and that using HP-B-CD to formulate an aqueous minoxidil solution warrants further investigation.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 1000+ results

      community Alternatives to Minox for pet safety

      in Minoxidil  2 upvotes 1 week ago
      The conversation discusses alternatives to minoxidil for beard growth, focusing on a product called Neofollics Beard Growth Serum, which claims to be effective without using minoxidil. Concerns are raised about its ingredients and effectiveness, especially considering pet safety.

      community What ketoconazole shampoo do you use?

      in Ketoconazole  8 upvotes 7 months ago
      Nizoral is commonly used for hair loss and dandruff, but it can cause dryness; users often pair it with conditioners or alternative shampoos. Some also use finasteride, minoxidil, and red light therapy for hair care.

      community What to expect switching from 2% to 5% minoxidil?

      in Minoxidil 3 months ago
      A user switched from 2% to 5% minoxidil, alongside using finasteride and dermarolling, to address hair thinning and is curious about potential shedding. They have not experienced noticeable hair loss or shedding since starting the treatment.

      community Long term take(15-20y) 2.5mg oral minoxidil safe?

      in Minoxidil  55 upvotes 3 months ago
      An 18-year-old is considering taking 2.5mg oral minoxidil for 15-20 years alongside dutasteride and finasteride. They are concerned about the long-term safety and effectiveness of minoxidil in maintaining hair stability.

    Related Research

    1 / 1 results