miR-195-5p Regulates Hair Follicle Inductivity of Dermal Papilla Cells by Suppressing Wnt/β-Catenin Activation

In the 2018 study, researchers explored the impact of miR-195-5p on the hair follicle inductivity of dermal papilla (DP) cells, particularly its role in the Wnt/β-catenin signaling pathway. They discovered that miR-195-5p was more abundant in late-passage DP cells, which lack the ability to induce hair follicle development, and less abundant in early-passage DP cells, which retain this inductive capacity. Overexpression of miR-195-5p resulted in a dose-dependent reduction of β-catenin expression and decreased levels of LRP6 and other genes involved in hair follicle inductivity. The study concluded that miR-195-5p suppresses Wnt/β-catenin signaling, which may lead to the loss of hair follicle inductivity in DP cells. The findings provide potential targets for maintaining or restoring the hair-inducing capacity of DP cells and were supported by data available in the Gene Expression Omnibus under accession number GSE77825.