Mir-325-3p Functions as a Suppressor Mirna and Inhibits the Proliferation and Metastasis of Glioma Through Targeting Foxm1

The study found that miR-325-3p functioned as a suppressor miRNA in glioma by targeting the FOXM1 gene, which is linked to tumorigenesis. MiR-325-3p was underexpressed in glioma tissues, and its upregulation in cell lines reduced cell viability, proliferation, migration, and invasion. In vivo experiments in mice confirmed that miR-325-3p suppressed tumor growth. The inverse relationship between miR-325-3p and FOXM1 expression suggested that the miR-325-3p/FOXM1 pathway could be a promising therapeutic target for glioma treatment, offering new insights into the molecular mechanisms of glioma progression.