Molecular Mechanisms of Hair Follicle Development

January 2024 in “ The Scientific World JOURNAL ”

Mebrie Zemene Kinde, Tewodros Abere Mekuria, Abebe Tesfaye Gessese, Bemrew Admassu Mengistu

hair follicles Wnt signaling pathway Shh signaling pathway Notch signaling pathway BMP signaling pathway stem cell fate cytodifferentiation hair loss organogenesis

TLDR Understanding hair follicle development helps create treatments for hair loss and improve hair health.

The document reviews the molecular mechanisms of hair follicle (HF) development, focusing on the stages of induction, organogenesis, and cytodifferentiation, regulated by pathways like Wnt, Shh, and BMP. These processes are crucial for developing treatments for hair loss conditions such as androgenetic alopecia and alopecia areata, with drugs like minoxidil, finasteride, and JAK inhibitors showing effectiveness. Advances in HF biology have also contributed to regenerative medicine, with techniques like 3D bioprinting and stem cell therapies offering potential for hair restoration. Despite these advancements, challenges such as the complexity of HF biology, disorder heterogeneity, and regulatory and financial hurdles remain. Understanding HF biology has also improved wound healing and led to personalized therapies and cosmetic treatments.

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research Recent Progress in Hair Follicle Stem Cell Markers and Their Regulatory Roles

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research Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration

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research Perspectives and Challenges of Hair Analysis

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research Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

May 2023 in “Clinical, Cosmetic and Investigational Dermatology”

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research Role and Mechanisms of Phytochemicals in Hair Growth and Health

2 citations , January 2023 in “Pharmaceuticals”

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research Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature

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research An Overview of the Genetic Aspects of Hair Loss and Its Connection with Nutrition

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research Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis

4 citations , July 2022 in “Frontiers in Cell and Developmental Biology”

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research Topical and Nutricosmetic Products for Healthy Hair and Dermal Anti-Aging Using Dual-Acting Plant-Based Peptides, Hormones, and Cannabinoids

13 citations , May 2021 in “FASEB bioAdvances”

Plant-based products can improve hair and skin health without harmful side effects.

research Functional Hair Follicle Regeneration: An Updated Review

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An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

research An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities

23 citations , December 2020 in “Frontiers in Cell and Developmental Biology”

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research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations , July 2020 in “International Journal of Molecular Sciences”

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research Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal?

29 citations , December 2019 in “Stem Cells Translational Medicine”

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Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

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research The Role of Vitamins and Minerals in Hair Loss: A Review

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research Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata

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research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations , September 2016 in “JCI insight”

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research Serum Biotin Levels in Women Complaining of Hair Loss

71 citations , January 2016 in “International Journal of Trichology”

Biotin deficiency is not a major cause of hair loss in women, so biotin supplements are not likely to be an effective hair loss treatment.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations , January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Early Inductive Events in Ectodermal Appendage Morphogenesis

160 citations , January 2014 in “Seminars in cell & developmental biology”

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The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

66 citations , June 2013 in “Journal of Dermatological Treatment”

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research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

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research Stem Cells in Embryonic Skin Development

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research Review of Hair Follicle Dermal Cells

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research KGF And EGF Signaling Block Hair Follicle Induction And Promote Interfollicular Epidermal Fate In Developing Mouse Skin

82 citations , May 2009 in “Development”

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research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

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research The Biology of Hair Growth

10 citations , January 2009 in “Elsevier eBooks”

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research Laminin-511 Is an Epithelial Message Promoting Dermal Papilla Development and Function During Early Hair Morphogenesis

102 citations , August 2008 in “Genes & Development”

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research Activation of Beta-Catenin Signaling Programs Embryonic Epidermis to Hair Follicle Fate

193 citations , May 2008 in “Development”

Activating β-catenin can turn skin cells into hair follicles.

research Scratching the Surface of Skin Development

788 citations , February 2007 in “Nature”

The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

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research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

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research Towards a Molecular Understanding of Hair Loss and Its Treatment

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