Advances In The Molecular Pathogenesis And Targeted Therapy Of Psoriasis

    May 2025 in “ Galen Medical Journal ”
    Parivash Shokoufa, M Afzal Aghaei
    Psoriasis affects 2-3% of the global population and involves immune dysregulation, keratinocyte dysfunction, and genetic/epigenetic changes, with comorbidities like psoriatic arthritis and cardiovascular disease. Recent advances using single-cell RNA sequencing and transcriptomics have identified key mechanisms such as GSDME-mediated pyroptosis and IL-23/IL-17 axis activation. Targeted therapies, including IL-17 inhibitors like secukinumab and IL-23 inhibitors like risankizumab, show promise, while novel treatments like hyperforin and Deu@Cal microneedles are in early stages. Challenges include adverse events, treatment resistance, and personalization gaps. Future efforts focus on multi-omics integration and combination therapies to enhance precision medicine in psoriasis management.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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      in Progress Pictures  492 upvotes 3 years ago
      A user who shared progress pictures of their scalp using a microscope camera, demonstrating the difference between healthy and miniaturized hair. Various explanations for the cause of this were discussed, such as DHT build-up in scalp sebum causing an autoimmune response leading to inflammation and eventual hair loss, with some suggesting a do-it-yourself treatment involving adding ascorbic acid powder to shampoo.

      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  32 upvotes 2 months ago
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      community Lost density 60% all over scalp in 120 days (4months)

      in Update  10 upvotes 1 year ago
      A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

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      in Treatment  58 upvotes 4 years ago
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